(1) Journal Source
Progress in Retinal and Eye Research (2026, Vol. 115, Article 101531).

(2) Title
Retinopathy of prematurity in the anti-VEGF era: Screening systems and practical treatment decision-making across anti-VEGF, laser, and surgery.

(3) Research Approach
This review integrates ROP retinal vascular developmental mechanisms, ICROP3 classification, screening and telemedicine/artificial intelligence, postnatal weight-gain risk stratification, and treatment selection among anti-VEGF, laser, and surgery, together with long-term outcomes. It links persistent avascular retina, delayed reactivation, systemic drug exposure, and follow-up burden after anti-VEGF therapy into an evidence framework spanning screening, treatment, and longitudinal surveillance.

(4) Innovation
It frames screening systems as a core part of the treatment pathway; emphasizes that treatment success in the anti-VEGF era extends beyond short-term regression to continued peripheral vascular maturation, prevention of delayed reactivation and tractional complications; and proposes individualized decisions based on disease zone, infant systemic status, and follow-up capacity, while comparing systemic exposure profiles of anti-VEGF agents.

(5) Material/Intervention Development
As a review, this article does not develop new biomaterials. It discusses anti-VEGF agents including bevacizumab, ranibizumab, aflibercept, conbercept, and faricimab, as well as laser photocoagulation, vitreous surgery, and topical dexamethasone; faricimab and topical dexamethasone remain investigational strategies.

We provide full-process services for various material designs (including highly innovative scheme design, preparation, characterization, in vitro and in vivo validation (cell/animal experiments), etc.): a postdoctoral team (with multiple high-impact publications in Zone 1 journals) can meet all kinds of tricky and challenging requirements, including hydrogels / drug delivery / nanomaterials / polymers / liposomes / microneedle drug delivery, etc. We can assist with project design / NSFC grant applications / publication of high-impact Zone 1 and Zone 2 papers in journals such as AFM, SCI, AM, etc. Welcome to consult 👇️
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