Ⅰ. Research Overview

A complex pathological microenvironment develops following myocardial infarction, and conventional therapies struggle to address massive cardiomyocyte loss. This review focuses on heart‑tailored hydrogels, sorting out their multiple properties including conductivity, adhesiveness and anisotropy. It discusses how hydrogels adapt to the pathological features of infarcted hearts to achieve myocardial injury repair.

Ⅱ. Core Innovative Highlights

It systematically summarizes the physicochemical properties of hydrogels adapted to cardiac physiological characteristics. It sorts out two major application directions of hydrogels: as scaffolds and delivery vehicles, summarizes loading strategies for bioactive agents such as cells, nucleic acids and growth factors, and analyzes various research‑level challenges of existing material systems.

Ⅲ. Key Material Design and Validation

Hydrogels mimic the myocardial extracellular matrix with balanced properties of mechanics, conductivity, biodegradability and adhesiveness. Injectable systems can be constructed to carry diverse bioactive components. Biological evaluations are performed in vitro and in animal models to regulate local inflammation, angiogenesis and ventricular remodeling processes.

Ⅳ. Insights and Outlook

(1) Reverse‑thinking: Instead of merely pursuing outstanding single‑property performance, match dynamic physicochemical properties of materials to the complex time‑dependent pathological changes after myocardial infarction.

(2) Systematic design: Integrate mechanical support, electrical conduction, bioactive‑agent delivery and immune regulation within a single hydrogel system.

(3) Platform potential: Provide a systematic reference framework for developing functional hydrogels targeting myocardial infarction repair.

Ⅴ. Article Information

(1) Journal Source: Molecular Pharmaceutics

(2) Article Title: Insight into Heart‑Tailored Architectures of Hydrogel to Restore Cardiac Functions after Myocardial Infarction

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