1. Journal Source: Chemical Engineering Journal

2. Title: Redox‑responsive MOF‑based nano‑inducer with cascade‑enhanced multienzyme activities for synergistic tumor therapy

3. Research Highlights: In this work, a redox-responsive MOF-based nano-inducer was designed. A porous bimetallic Co/Fe-MOF was used as the carrier to load Nb₂C@Cu₂O and AIE molecules, with polydopamine and aptamers modified on the outer layer. Relying on multi-enzyme mimicking activities, combined with photothermal/photodynamic therapy, chemodynamic therapy and PD-L1 immune checkpoint blockade, cascade synergistic inhibition of hepatocellular carcinoma was achieved.

4. Innovations: A quaternary Cu/Co/Fe/Nb component system was constructed to realize cascade amplification of multiple effects; the entire action pathway from microenvironment remodeling and oxidative stress activation to immunogenic cell death was fully elucidated; a bilateral tumor model was adopted to systematically investigate the material-mediated in situ and distal anti-tumor immune responses.

5. Material Development (1) Materials: CCP (Apt/PDA@Co/Fe-MOF@Nb₂C@Cu₂O/AIE) nanomaterials were fabricated via layer-by-layer self-assembly. (2) Functions: It exhibits multi-enzyme-like activities including GPx, POD, CAT and OXD, which can consume GSH, decompose H₂O₂ to produce oxygen for hypoxia alleviation and generate reactive oxygen species. It also possesses photothermal and photodynamic effects, as well as dual-modal imaging capacities of T2-weighted magnetic resonance imaging and photothermal imaging.

6. Outlook: This study provides a strategy for the construction of highly active multi-functional nanozymes. It can be extended to other solid tumors, and further exploration can be carried out to reveal the regulatory rule of different metal ratios on the cascade catalytic pathways.

#MOF #nanozyme #synergistic tumor therapy #nanobiomaterial #chemodynamic therapy #literature sharing

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