1. Journal Source: ACS Nano


2. Title: Starfish‑Inspired Synergistic Reinforced Hydrogel Wound Dressing: Dual Responsiveness and Enhanced Bioactive Compound Delivery for Advanced Skin Regeneration and Management


3. Research Highlights: In this work, a starfish-inspired synergistically reinforced hydrogel dressing is designed. Relying on dynamic crosslinking networks of Schiff base and boronate ester, it is loaded with mangiferin and vitamin C. It can release active substances in a controlled manner in response to changes in wound pH and ROS, possesses multiple composite properties, regulates the wound microenvironment, and facilitates the repair and regeneration of skin tissue.


4. Innovations: A hydrogel crosslinked with multiple dynamic bonds is constructed by drawing on the physiological characteristics of starfish; pH‑ROS dual-stimuli-responsive drug release is realized; multiple functions including 3D printability, injectability, self-adhesion and self-healing are integrated in one system; finite element simulation is adopted to verify the release behavior of active substances.


5. Material Development (1) Materials: dopamine-modified cellulose nanofibers, chitosan, aminophenylboronic acid-grafted oxidized dextran, polyvinyl alcohol; loaded with mangiferin and vitamin C. (2) Functions: injectable, 3D printable, self-adhesive, self-healing; hemostatic, antibacterial, reactive oxygen species scavenging; dual microenvironment-responsive controlled release of active components, inflammation regulation, promotion of tissue regeneration, and favorable biocompatibility.

#ScientificResearch #Literature #WoundHealing #Hydrogel #MedicineEngineeringInterdiscipline

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