(1) Journal source: Theranostics, 2026, 16(12): 6437–6462 

(2) Title: Scalable Differentiation of Human Cardiac Organoids from iPSCs to Generate Cardiac Tissues for Cardiac Cell Therapy

(3) Research rationale: This work establishes an induced pluripotent stem cell (iPSC)-based differentiation system for scalable fabrication of cardiac organoids to yield three-dimensional cardiac tissues. The tissue characteristics are characterized, and the transplantation performance of these organoids is investigated in animal models. 

(4) Innovations: Scalable production of iPSC-derived cardiac organoids; the organoids contain cardiac cell populations and recapitulate tissue architecture; successful engraftment after transplantation in large-animal cardiac models with no observed adverse events. 

(5) Material development

Material: Three-dimensional cardiac organoids derived from human induced pluripotent stem cells (iPSCs)

Functions: Recapitulate the multicellular composition and structural features of native cardiac tissue, possess the biological properties of cardiac tissue, and can be applied in cardiovascular research.

We provide full-process services for custom material design, including innovative scheme design, fabrication, characterization, and in vitro & in vivo validation (cell and animal studies). Our postdoctoral team with multiple high-impact Q1 publications can tackle your challenging research demands. Our scope covers hydrogels, drug delivery systems, nanomaterials, polymers, liposomes, microneedles and more. We support project design, NSFC proposal writing, and high-quality SCI manuscripts for journals such as AFM, AM and other Q1/Q2 journals. Enquiries are welcome

17768014569 (Dr.Gao)

17761925168 (Dr. Zhang)

18013729810 (Dr. Yang)