(1) Journal Source: Chemical Engineering Journal

(2) Title: An injectable double‑crosslinked Bletilla Striata polysaccharide hydrogel encapsulating Mg‑SalB nanoparticles for smart diabetic wound therapy

(3) Research Highlights: This study designs an injectable double-crosslinked GBMA@Mg‑SalB composite hydrogel incorporating magnesium-salvianolic acid B metallopolyphenol nanoparticles to construct a glucose/ROS dual-responsive system. The effects of this material on microenvironment reprogramming and wound repair of diabetic ulcers are investigated at cellular, rat and Bama miniature pig levels.

(4) Innovations: ① A gelatin-Bletilla striata polysaccharide double-crosslinked network containing dynamic boronate ester bonds and photocrosslinking is fabricated to realize injectability and in-situ gelation; ② Mg‑SalB metallopolyphenol coordination nanoparticles are loaded to achieve on-demand sequential drug release under the pathological microenvironment with high glucose and excessive ROS; ③ Multiple biological effects including antioxidation, macrophage phenotype modulation and pro-angiogenesis are achieved simultaneously; ④ Pharmacodynamic verification is performed using multiple animal models including rat back wounds, rat foot wounds and Bama miniature pigs.

(5) Material Development (1) Materials: APBA-modified gelatin (GBA), methacrylated Bletilla striata polysaccharide (BSPMA); magnesium-salvianolic acid B coordination nanoparticles (Mg‑SalB); GBMA@Mg‑SalB hydrogel is obtained by compounding the above components. (2) Functions: It possesses injectability, self-healing capacity and tissue adhesion; it undergoes dual-stimuli-responsive degradation and drug release triggered by glucose and ROS; it scavenges reactive oxygen species and induces macrophage polarization toward the M2 phenotype; released magnesium ions synergize with salvianolic acid B to promote angiogenesis and remodel the wound microenvironment.

(6) Outlook: The fabrication process of Mg‑SalB nanoparticles can be further optimized; this dual-responsive hydrogel can be extended to other types of chronic wounds; other bioactive molecules can be integrated to expand the multifunctional properties of the material.

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