Jason A. Burdick from the University of Pennsylvania reviewed the research on chemically modified biopolymers used to form biomedical hydrogels.



Key points of this article:

(1) Biopolymers refer to natural polymers from plants and animals, including various types of polysaccharides and peptides. Biopolymers are used to construct hydrogels for biomedical applications due to their inherent biochemical and biophysical properties (such as cell adhesion, degradability, and viscoelasticity). This field is also currently causing research Wide interest of the audience.





(2) In the article, the author reviews the design and development of biopolymer hydrogels, focusing on the methods of chemical modification and cross-linking of biopolymers. First, the author introduced the basic theory of biopolymers and the chemical coupling method of introducing crosslinking groups. Then, the author discussed in detail including (1) covalent crosslinking, (2) dynamic covalent crosslinking and (3) Various methods of forming biopolymer networks including physical crosslinking; finally, the author focuses on the use of chemically modified biopolymer hydrogels in the construction of tissue scaffolds, delivery of therapeutic drugs, as tissue adhesives, and construction of biopolymers. The latest research progress in biohydrogels.


references:

Victoria G. Muir. et al. Chemically Modified Biopolymers for the Formation of Biomedical Hydrogels. Chemical Reviews. 2020

DOI: 10.1021/acs.chemrev.0c00923

https://pubs.acs.org/doi/10.1021/acs.chemrev.0c00923

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