📌 Journal Source: Nature Communications (IF 15.7)

📌 Title: Organodiselenide Hydrogel Microspheres for Multimodal Therapy of Osteoarthritis

📌 Research Idea: This study designed a ROS/MMP13 dual-responsive organoselenium hydrogel microsphere (HSPHR). By targeting the pathological features of osteoarthritis (OA), such as abnormal local microenvironment, it synchronously regulates selenoprotein levels in cartilage, synovium and subchondral bone to achieve multimodal synergistic therapy.

📌 Material Development: (1) Material: Organodiselenide hydrogel microspheres (HSPHR) (2) Functions: Trigger therapeutic effects in response to the pathological microenvironment (ROS/MMP13); elevate selenoprotein levels in key tissues; inhibit cartilage damage, synovial hyperplasia and osteosclerosis; promote neocartilage formation and serum protein synthesis; activate the PI3K-AKT-mTOR pathway to improve mitochondrial function.

📌 Innovations: Pioneering the "pathological feature-triggered" therapeutic strategy: the material function is specifically activated by the OA microenvironment; multimodal synergistic mechanism: simultaneous regulation of three types of diseased tissues (cartilage/synovium/subchondral bone); elucidation of the cross-cellular pathway: the PI3K-AKT-mTOR pathway is verified as the core regulatory pathway for reversing OA.

#ScientificResearch #MedicineEngineeringIntersection #Medicine #MedicalSCI #MedicalResearch #Literature #Biomaterials #Osteoarthritis #NatureSubjournal

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