(1) Journal Source
Progress in Retinal and Eye Research (2026).

(2) Title
Omics in optic neuropathies: From molecular landscapes to personalized therapeutics.

(3) Research Approach
Focusing on the heterogeneity of optic neuropathies, this review summarizes the application of genomics, transcriptomics, proteomics, metabolomics, lipidomics, microbiomics, and single-cell sequencing. It analyzes pathogenic mechanisms layer by layer, from DNA variations, RNA expression, protein function, and metabolic remodeling to microbial interactions and single-cell resolution, and discusses their value in biomarker screening and individualized therapeutic strategies.

(4) Innovation
It systematically constructs a panoramic multi-omics atlas of optic neuropathies, overcoming the limitations of single-omics approaches. It proposes a framework mapping omics findings to pathological phenotypes (e.g., mitochondrial dysfunction, axonal transport defects, immune dyshomeostasis, and metabolic dysregulation) and highlights the key role of single-cell and spatial omics in deciphering retinal ganglion cell (RGC) subpopulation heterogeneity and microenvironment remodeling.

(5) Material Development
As a review, this article does not involve the development or characterization of nanomaterials, biomaterials, or drug delivery systems. It primarily focuses on the progress of omics technologies themselves, multi-dimensional data integration, and bioinformatic analysis methods.

(6) Future Directions
Future studies should incorporate difficult-to-access samples (e.g., cerebrospinal fluid, optic nerve tissue) and cross-ethnic cohorts to improve representativeness; promote data standardization and AI-driven systems biology integration; and combine materials science (e.g., designing biodegradable scaffolds loaded with neurotrophic factors) with gene editing to explore precise interventions for specific cell subpopulations.

We provide full-process services for various material designs (including highly innovative scheme design, preparation, characterization, in vitro and in vivo validation (cell/animal experiments), etc.): a postdoctoral team (with multiple high-impact publications in Zone 1 journals) can meet all kinds of tricky and challenging requirements, including hydrogels / drug delivery / nanomaterials / polymers / liposomes / microneedle drug delivery, etc. We can assist with project design / NSFC grant applications / publication of high-impact Zone 1 and Zone 2 papers in journals such as AFM, SCI, AM, etc. Welcome to consult 👇️
17768014569 (Senior Engineer Gao)
17761925168 (Engineer Zhang)
18013729810 (Engineer Yang)

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