（1）Journal Source:

Advanced Functional Materials (IF: 19)

（2）Title:

Ultrasound-Activated Nanoprobiotic Hydrogel Disrupts the Oral–Brain Axis to Alleviate Diabetic Periodontitis and Cognitive Decline

（3）Research Rationale:

Herein, an ultrasound-responsive, polyphenol-engineered artificial nanoprobiotic hydrogel is designed. It achieves microenvironment-responsive antibacterial activity by narrowing the band gap to boost sonodynamic performance, restores the balance of the oral microbiota, uses zinc ions to bidirectionally regulate bone metabolism, and relieves cognitive decline via modulation of the oral–brain axis, thereby breaking the vicious cycle between diabetic periodontitis and cognitive impairment.

（4）Material Development:

Materials: A dihydrocaffeic acid-mediated Fe/Zn bimetallic porphyrinic metal–organic framework as the core, integrated into a self-adaptive hydrogel.

Functions: Ultrasound activation narrows the band gap and enhances sonodynamic performance for antibacterial effects; dihydrocaffeic acid restores oral microecological homeostasis; zinc ions inhibit osteoclasts and activate osteoblasts to orchestrate bone remodeling; modulation of the oral–brain axis mitigates anxiety-like behaviors.

（5）Highlights:

For the first time, an ultrasound-activated nanoprobiotic hydrogel is proposed for concurrent treatment of diabetic periodontitis and its associated cognitive decline, breaking the oral–systemic disease cycle.

It reveals the pivotal role of the oral–brain axis in cognitive impairment linked to diabetic periodontitis, offering new insights into microbiome–brain crosstalk.

Single-cell analysis identifies macrophage–fibroblast crosstalk as a core driver of periodontal regeneration.

We provide full-process services for custom material design, including innovative scheme design, fabrication, characterization, and in vitro & in vivo validation (cell and animal studies). Our postdoctoral team with multiple high-impact Q1 publications can tackle your challenging research demands. Our scope covers hydrogels, drug delivery systems, nanomaterials, polymers, liposomes, microneedles and more. We support project design, NSFC proposal writing, and high-quality SCI manuscripts for journals such as AFM, AM and other Q1/Q2 journals. Enquiries are welcome

17768014569 (Dr.Gao)

17761925168 (Dr. Zhang)

18013729810 (Dr. Yang)