1. Journal Source: Chemical Engineering Journal


2. Original Title: Glucose‑driven chemodynamic therapy and gas therapy for diabetic infection via multifunctional copper‑guanosine hydrogel


3. Research Highlights: In this work, a hyaluronic acid-modified copper-guanosine hydrogel Cu-GBGA@HA was designed to construct a dual-cascade enzymatic system that synergistically integrates chemodynamic therapy and gas therapy. The therapeutic effect is triggered by the pathological microenvironment of wounds to achieve targeted action against pathogens for the management of diabetic infected wounds.


4. Innovations: 1. A glucose-driven dual-cascade catalytic pathway is constructed. Endogenous glucose is utilized to initiate Fenton-like reactions for reactive oxygen species (ROS) generation, meanwhile realizing on-demand nitric oxide (NO) release; 2. A hyaluronic acid shell is introduced, which can be degraded by enzymes secreted by bacteria to achieve pathogen-specific targeted activation of therapy; 3. The hydrogel features injectability, shear-thinning and self-healing properties. It can maintain a moist wound microenvironment and reduce mechanical damage caused by dressing changes.


5. Material Development: (1) Materials: Using guanosine-boronic acid as the backbone, Cu-G4 hydrogel is obtained via copper ion coordination. After encapsulating glucose oxidase and L-arginine and grafting activated hyaluronic acid, Cu-GBGA@HA is fabricated. (2) Functions: Exhibits peroxidase-like catalytic activity; injectable, self-healable and moderately swellable; generates ROS and NO through dual-cascade catalysis; possesses favorable biocompatibility.

6. Prospect Outlook: Only qualitative analysis via tissue staining was performed in this study. Immunohistochemistry and immunofluorescence characterization can be supplemented in follow-up research to further elucidate the molecular mechanisms underlying wound repair.

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