(1) Journal Source: *Advanced Materials*

(2) Title: Nanoscale Interception for Heart Failure: Prussian Blue Particles Targeting Communication Pathways

(3) Research Rationale: Targeting the pathological fibrotic‑inflammatory network in heart failure, Prussian blue nanoparticles are engineered to target the key chemokine axis and block crosstalk between fibroblasts and immune cells.

(4) Innovations: It acts by directly targeting intercellular communication rather than intracellular pathway intervention. Distinct from conventional nanomaterials, this strategy does not require systemic immunosuppression.

 (5) Material Development:

① Material: Scalable synthetic Prussian blue nanoparticles

② Function: Binds chemokines with high affinity to inhibit receptor binding and restore cardiac function.

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