(1) Journal Source: Advanced Functional Materials

(2) Title: A Potent Nickel-Based STING Agonist Nanomedicine for the Treatment of Bone Metastasis of Prostate Cancer

(3) Research Idea: In this study, a carbon-supported nickel oxide nanomedicine (C@NiOₓ) was designed. Atomic Layer Deposition (ALD) technology was adopted to regulate immune responses by optimizing nanostructures. Targeting the dual pathological mechanisms of prostate cancer bone metastasis (tumor growth and metastasis as well as bone pain), high-efficiency anti-tumor effects were achieved.

(4) Material Development: Material: carbon-supported nickel oxide nanomedicine (C@NiOₓ). Functions: enhancing interfacial electron transfer properties, optimizing catalytic performance and boosting the production of reactive oxygen species (ROS). It inhibits tumor growth and metastasis and alleviates bone pain through ROS-dependent immunogenic cell death and STING pathway activation mechanisms.

(5) Innovations: ALD technology was used to realize precise size control, and carbon-metal interfacial bonding was combined to improve electron transfer efficiency, breaking the immunomodulatory limitations of conventional nickel oxide nanoparticles. Meanwhile, it targets malignant progression and the immunosuppressive bone microenvironment to establish a novel anti-hyperthermia therapeutic paradigm.

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