(1) Journal: Advanced Science, 07 May 2026

(2) Title: Aptamer‑Directed Porous DNA Nanocomposite Hydrogel for Active Pulp Preservation: Immunomodulation, Stem Cell Recruitment and Reparative Dentinogenesis

(3) Research rationale: An aptamer-directed porous DNA nanocomposite hydrogel was designed and evaluated in a pulp injury model. With the porous network structure of the hydrogel and the targeting property of aptamers, the underlying mechanisms of the material in modulating the local immune microenvironment, recruiting endogenous stem cells and triggering reparative dentinogenesis were investigated.

(4) Innovations: The aptamer targeting moiety was integrated into the porous DNA hydrogel platform. The material permits in-situ photocuring, which accomplishes immunoregulation and endogenous stem cell recruitment in one step. DNA-based biomaterials are demonstrated to induce reparative dentin formation, providing an alternative design strategy for pulp-preserving biomaterials.

(5) Material development

1. Material: Aptamer-directed porous DNA nanocomposite hydrogel

2. Functions: In-situ photocurable, modulates local immune microenvironment, recruits endogenous stem cells and induces reparative dentin formation for pulp injury repair.

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