生物正交反应调控的纳米探针与药物是一种利用特定的化学反应在生物体内实现纳米探针与药物的精准结合和释放的方法。这种方法可以克服传统的纳米药物递送系统的局限性，如低靶向性、高毒性、不稳定性等，实现对疾病的高效诊断和治疗。 

The combination of nanoparticles and bioorthogonal chemistry, and for applications in bioimaging, biosensing, drug delivery, and activation. It mentioned a nanoprobe based on the copper-catalyzed azide-alkyne cycloaddition reaction (CuAAC) to release the anticancer drug docetaxel (doxorubicin) at the tumor site to achieve efficient killing of liver cancer cells.

The application of bioorthogonal chemical reactions in biomolecular analysis and disease diagnosis, including the detection of endogenous molecules such as proteins, nucleic acids, metabolites, enzyme activities, and the determination of disease-related targets. A nanoprobe based on tetrazine-diene reaction (Tz-Di) can release fluorescent dyes and anticancer drugs at the tumor site to combined photodynamic / chemical therapy of breast cancer cells.

A nanoprobe based on light-induced bioorthogonal response (PIBR) can release photosensitizers and anti-cancer drugs at tumor sites to combined photodynamic / chemical therapy of lung cancer cells.

参考文献：

[1]Nanoparticles and bioorthogonal chemistry joining forces for improved biomedical applications.

[2]Research Progress and Application of Bioorthogonal Reactions in Biomolecular Analysis and Disease Diagnosis.

[3]Nanoparticles and bioorthogonal chemistry joining forces for improved biomedical applications.