Magnetoelectric Nanomaterials: New Exploration for Periodontitis Synergistic Therapy 

(1) Journal source: 

Advanced Materials (AM) 

(2) Title: 

Study on Magnetoelectric Coupling Core‑Shell Nanomaterials for Antibiosis, Immunomodulation and Osteogenic Repair of Periodontitis 

(3) Research idea: 

This work designs a type of magnetoelectric coupling core-shell nanomaterial. Aiming at persistent inflammation, bacterial invasion and bone tissue defects in periodontitis, the magnetoelectric coupling effect is introduced into the periodontal repair system. Remote regulation by an external magnetic field enables simultaneous antibacterial activity, macrophage phenotypic reprogramming and osteogenic induction of stem cells. Transcriptomics and pathway inhibition assays are adopted to dissect the molecular pathway, and its effects on periodontal inflammation and bone repair are verified in animal models. 

(4) Material development:

① Materials: CoFe₂O₄@BiFeO₃ core-shell magnetoelectric nanomaterial; 

② Functions: Realize magneto-mechano-electro-chemical signal conversion under external magnetic field stimulation, generate ROS for antibacterial and biofilm elimination, regulate macrophage polarization, and induce osteogenic differentiation of periodontal ligament stem cells. The material maintains structural stability in the oral microenvironment and possesses favorable biocompatibility.

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