Wireless hydrogel patch for periodontitis sensing and therapy 

 (1) Journal source:

 National Science Review (NSR)

 (2) Title: 

Wireless passive hydrogel bioelectronic patch for wireless detection of periodontitis inflammatory signals and local miRNA immunotherapy

 (3) Research idea: 

This work designs a wireless passive hydrogel bioelectronic patch. To address the limitation that conventional periodontitis evaluation cannot provide molecular-level inflammatory information and routine administration fails to sustain effective drug concentration at lesion sites, it integrates flexible radiofrequency devices and inflammation-responsive hydrogel to convert local periodontal biomarker information into wirelessly readable radiofrequency signals, enabling concomitant local intervention.

 (4) Material development:

① Materials: Miniaturized flexible radiofrequency devices fabricated by aerosol jet printing, MMP‑9-responsive hydrogel; 

② Functions: Recognize periodontal biomarker MMP‑9. Enzymatic cleavage triggers hydrogel degradation and shifts the resonant frequency of the device for dynamic inflammatory sensing, while loaded miRNA mediates local immune regulation.

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