Journal Source

Bioactive Materials

Title

Hierarchical Nanorocket for spatially coordinated regulation of glycosaminoglycan deposition and metabolism in cartilage

Research Idea

This study designs a hierarchical "Nanorocket" delivery system integrating extracellular glycosaminoglycan deposition in cartilage with intracellular enrichment and degradation regulation of glycosaminoglycans in chondrocytes. Its dual‑module structure enables deep cartilage penetration and prolonged intra‑articular retention. The extracellular module replenishes matrix glycosaminoglycans while the intracellular module modulates relevant gene expression to jointly maintain glycosaminoglycan homeostasis and explore its intervention efficacy against osteoarthritis.

Innovations

A nanoplatform for spatially coordinated regulation is constructed to realize anchorable replenishment of extracellular‑matrix glycosaminoglycans as well as intracellular silencing of glycometabolic genes and promotion of biosynthesis. Cationic peptides facilitate deep cartilage penetration, and the modular structure achieves site‑specific release, coordinating extracellular matrix remodeling and intracellular metabolic modulation.

Material Development

(1) Materials: The hierarchical Nanorocket is assembled from the HDMBr/siADAMTS5 Satellite module and the chondroitin sulfate‑cationic peptide Booster module. (2) Functions: It achieves deep cartilage penetration and long‑term intra‑articular retention. The Booster anchors to the extracellular collagen network to replenish glycosaminoglycans. Internalized Satellite suppresses proteoglycan degradation and facilitates glycosaminoglycan synthesis and secretion in chondrocytes.

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