Intelligent drug delivery system is a kind of using external stimuli or endogenous signal to achieve drug or gene in the body accurate, controllable and efficient delivery technology, it can according to the nature of the drug, the characteristics of the target tissue, the change of pathological state factors, design different response mechanism and release mode, in order to achieve the timing, quantitative, orientation and positioning of drug delivery. Intelligent drug delivery system can overcome the defects of the traditional drug delivery system, such as the uneven distribution of drugs in the body, poor targeting, low bioavailability, and high toxic and side effects.

The active ingredient of Chinese medicine refers to the chemical ingredient of Chinese medicine with certain biological activity and therapeutic effects, such as alkaloids, flavonoids, saponins, polysaccharides and so on. TCM active ingredients have unique advantages in treating various diseases, such as multi-target, multi-level and collaborative intervention. However, there are also some problems with TCM active ingredients, such as poor water solubility, low stability and low bioavailability, which limit their clinical application. In addition, the active ingredients of TCM also have the phenomenon of "toxic-effect" transformation, that is, within a certain dose range, the active ingredients of TCM have therapeutic effect, but after a certain dose or time, they will produce toxic reactions or damage normal tissues.

This intelligent delivery system based on mesoporous silica nanoparticles can deliver the active Chinese medicine and docetaxel, the active western medicine, to overcome the multidrug resistance of tumors. This system uses pH-sensitive polymer as a gating mechanism to achieve controlled release in the tumor microenvironment while enhancing the synergy between resveratrol and docetaxel.

An intelligent delivery system based on the nanogel modified with reduction-sensitive hyaluronic acid can deliver the TCM active ingredient berberin and the western medicine active ingredient doxorubicin to enhance the anti-tumor effect. This system used hyaluronan receptor-mediated targeting to achieve efficient phagocytosis in tumor cells, while the rapid release in cells by breaking the reduction-sensitive bonding, and the synergistic effect between berberine and doxorubicin was used to enhance the anti-tumor effect.

Reference Documentation:

[1]Intelligent drug delivery systems for traditional Chinese medicine.

[2]Intelligent drug delivery system based on mesoporous silica nanoparticles for overcoming multidrug resistance in cancer.

[3]Intelligent drug delivery system based on redox-sensitive hyaluronic acid-decorated nanogels for the co-delivery of doxorubicin and berberine to enhance the antitumor effect.