In-vivo fate in the drug-carrier delivery system

Using cells as a drug carrier delivery system. Cells as drug carriers have the advantages of good biocompatibility, low immunogenicity, long circulation time, and tissue homing ability, which can effectively deliver drugs to tumor sites and avoid toxic and side effects of normal tissues. Using autoimmune cells (macrophages) as the carrier, the anticancer drug docetaxel was wrapped in PLA-PEG nanoparticles, and a cell-based drug delivery system was constructed to realize the efficient treatment of liver cancer. Using nanoparticles as a drug carrier delivery system for the photodynamic treatment of tumors. Photodynamic therapy is a therapeutic approach that uses photosensitizers to produce singlet oxygen or other reactive oxygen species for phototoxic killing of tumor cells. Nanoparticles as drug carriers can improve the stability, solubility and targeting of photosensitizers, as well as enhance their light absorption and conversion efficiency. A gold nanorods-based drug delivery system wrapping the photosensitizer polystyrene sulfate around the surface of gold nanorods and improves its biocompatibility and cycling stability by polyethylene G modification. This system can produce efficient singlet oxygen under near-infrared light excitation and achieve effective treatment for skin cancer and melanoma.

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