latelet-inspired nanoscale drugs
Platelet-inspired nanodrugs refer to the nanoscale drug carriers designed using the structural, functional or molecular features of platelets, which can achieve specific functions in or outside of living organisms, such as detection, imaging, delivery, diagnosis, treatment, etc. These nanomedicines can use the autonomous movement, perception, and adaptation of platelets to achieve targeted delivery to specific targets within the organism. These nanodrugs have the advantages of high efficiency, precision and safety, and can be used in various applications in the field of antitumor therapy. Case of platelet-inspired nanomedicine: Platelet membrane (platelet membrane) -based nanodrugs enable targeted delivery and immunomodulation in life. The platelet membrane is wrapped around a polymer core with drug loading capacity to form platelet-inspired nanodrugs. Such nanodrugs can use receptors and ligands on platelet membranes to achieve targeted delivery to tumor cells or immune cells and release drugs to achieve chemical killing or immune activation of tumor cells. Based on platelet DNA (platelet DNA), light-controlled motion and targeted delivery can be achieved in life. Folold platelet DNA molecules into nanodrugs with triangular frames and connect different types of functional molecules, such as fluorescent molecules, drug molecules, antibody molecules, at their vertices. Such nanomedicines can be used by external laser to control the direction and speed of their movement, and targeted delivery with other nanomedicines or biological cells by base pairing of DNA molecules. Based on platelet factor 4, platelet factor 4 (PF 4), it enables sound-controlled movement and targeted delivery in live vivo. PF 4 molecules were loaded on silicon-based carriers with hollow structures and sound wave responsiveness to form platelet-inspired nanodrugs. Such nanomedicines can be controlled in their movement direction and speed by external ultrasound, and can achieve targeted delivery to thrombus or tumor cells through the anticoagulation properties of PF 4 molecules.
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