The study of functionalized nanoclay in wound healing is a field of research that uses natural or synthetic clay materials, give them specific functions, and then apply it to wound healing. Functionalized nanoclay has good biocompatibility, biodegradable, antibacterial, anti-inflammatory, hemostatic, irritant, and drug loading capacity, which can promote the cleaning, moisturizing, healing, and reconstruction of the wound. Functionalized nanoclay can be prepared into different forms of wound dressings, such as powders, ointments, gels, films, etc., to accommodate different types and degrees of wounds.