Biomimetic structural materials are the cross-fusion of nanotechnology and biomedicine. They use nanotechnology (including nanomaterials) to study the characteristics of life bodies, discover new life phenomena and laws, and provide new theories and treatments for human health and disease diagnosis and treatment. method. With the development of nanobiomedicine, especially the discovery and application of the unique physical, chemical and biological properties of nanomaterials, new diagnosis and treatment technologies continue to emerge, and some traditional medical techniques and understanding have been changed. These nanomaterials themselves have become important diagnosis and treatment. Preparation (or medicine).



Figure 1. The application of nano-material diagnostic and therapeutic preparations based on metals, polymers, semiconductor quantum dots, carbon-based materials, and liposomes in the diagnosis and treatment of cancer [1]


Types and applications of biomedical nanomaterials

1

Magnetic Nanomaterials

It has very rich magnetic properties, such as superparamagnetism, Neel relaxation, Brownian relaxation, hysteresis effect, magnetic anisotropy, magnetic dipole interaction, alternating magnetocaloric effect, and movement characteristics in magnetic field gradients. Rich applications have been developed in biomedicine, such as magnetic resonance imaging contrast agents, magnetic targeting drug carriers, separation of cells and biomolecules, biosensing and detection, and magnetic induction tumor hyperthermia. The most famous clinical applications include the magnetic resonance contrast agent products developed by Advanced Magnetic Company of the United States and Schering Company of Germany, and the magnetic induction hyperthermia technology based on nano-iron oxide magnetic liquid (Nanotherm®) glioma developed by MagForce Company of Germany. The clinical application of FDA-approved nano-products has greatly encouraged the development of nano-biomedicine.




2




Metal nanomaterials

For example, gold and silver nanoparticles have unique optical properties such as surface plasmon resonance. They are used in surface-enhanced Raman scattering-based biosensing and imaging, biomarker dark-field imaging, gold-labeled immunochromatographic test strips, and tumor photothermal There are important applications in treatment and other fields.

3




Semiconductor nanoparticles

Group II-VI semiconductor quantum dots, such as CdSe/ZnS core-shell structure quantum dots, have become important fluorescent labels for biomolecules and cells due to their high-efficiency fluorescence emission caused by the quantum size effect. In recent years, new materials such as silicon quantum dots and near-infrared luminescent Ag2S quantum dots have opened up new fields in biomarking and imaging.

4




Carbon nanomaterials

Carbon nanomaterials are an important class of functional nanomaterials, such as fullerenes, carbon nanotubes, graphene, etc. Due to their excellent physical, chemical, electrical, thermal, mechanical and biological properties, they are used in optoelectronic materials and devices, structural materials , Catalysis and biomedical fields have broad application prospects.

5




Polymer nanomaterials

Since some polymer medical excipients (such as phospholipids, polyethylene glycol, PLGA, etc.) have been approved by the FDA, it is easier to obtain FDA approval for the development of drug delivery systems (DDS) based on these organic materials. Famous clinical applications include doxorubicin liposomes and paclitaxel albumin nanoparticles. These nano-drugs give full play to the advantages of DDS in reducing side effects and enhancing tumor drug accumulation. At the same time, drug carriers based on other functional polymers and natural polymers have also been greatly developed, and will play an important role in the development of smart drugs such as drug targeting and spatiotemporal controlled release in the future.




6




Multifunctional nanomaterials

This is based on the above-mentioned various functional nanoparticles and traditional diagnostic and therapeutic preparations. Through integration, compounding and other strategies, a nanoparticle system with multiple functions such as targeting, diagnosis (imaging), treatment, and reporting is constructed. Chemical treatment and integration of diagnosis and treatment will play an important role.



Biomedical Nanomaterials

Figure 2. All in One nano diagnosis and treatment platform



After years of research and development, Suzhou Beike Nano Technology Co., Ltd. has formed a series of biomedical magnetic nano materials, gold (silver) nano materials and other products with more than 300 specifications, and developed 8 nano drug delivery systems (liposomal drug delivery systems, Polymer micelle/capsule drug, polymer (protein, dendrimer) nanoparticle drug, nanoemulsion drug, magnetic lipid nanoparticle drug, gold nanoparticle (spherical particle, gold nanorod, gold nano Cage) drug-loaded, nano-graphene drug-loaded, smart gel drug-loaded) and 14 innovative technology service platforms. The quality is excellent, and it is well received by the majority of scientific research institutes and industrial customers. It has a wide range of applications in the fields of bioseparation detection, cell labeling, in vitro diagnosis, molecular imaging, drug carriers, tumor treatment, and antibacterial.



The company provides the following products:



Magnetic nanomaterials: PEGylated ferroferric oxide magnetic nanoparticles, gamma-ferroferric oxide magnetic nanoparticles, polylysine modified ferroferric oxide magnetic nanoparticles, carboxylated ferroferric oxide magnetic nanoparticles, Polyethyleneimine modified ferroferric oxide magnetic nanoparticles

Metal nanomaterials: water-soluble silver nanoparticles, water-soluble gold nanorods, water-soluble gold nanocages, special-shaped gold nanoparticles (gold nanochains, hollow gold nanoshells, gold nano triangles, gold nano stars, gold and silver nano shuttles, Gold nano double cone),

Carbon Nanomaterials: Magnetic Graphene

Magnetic beads series products: 1um carboxyl magnetic beads, 1um (low non-specific) carboxyl magnetic beads, 1um amino magnetic beads, 1um streptavidin magnetic beads

Multifunctional nanomaterials: Special nanomaterials designed and developed based on the design and preparation platform of micro and nano materials, surface modification and coupling technology platform, targeted nano probe construction platform, and nano drug delivery research and development platform.