Author: Huisong Hao Corresponding author: Wu Meiying, Chen Yu Communications Unit: Zhongshan University, Shanghai University

Nano-drug delivery systems have shown great potential in the diagnosis and treatment of various diseases due to their excellent characteristics, but they also face huge challenges, such as being easily recognized by the immune system and low accumulation in lesions.
The nanomedicine coated by cell membrane combines the good biocompatibility, targeting properties of natural cell membranes, prolonging blood half-life, reducing immunogenicity and other excellent characteristics, and the functional diversity of nanocarriers, which overcomes the shortcomings of traditional nanomedicine delivery systems , And show good development prospects in personalized diagnosis and treatment of diseases.
Up to now, although some reviews of nanomedicine on cell membrane biomimetic have been published, most of them have focused on the application of single diseases, especially tumors. This article mainly systematically summarizes the mechanism and advantages of cell membrane bionic nanomedicine in the diagnosis and treatment of various diseases.


Figure 1. Application summary of cell membrane biomimetic nanomedicine in disease diagnosis and treatment

In this review, the author systematically introduced the recent five-year research progress of cell membrane bionic nanomedicine in the diagnosis and treatment of various diseases, including cancer, bacterial infections, brain diseases, atherosclerosis, rheumatoid arthritis and diabetes, etc. , Reveals the mechanism of action of cell membrane bionic nanomedicine and the microenvironment of various diseases, and provides a basis for the establishment of bionic nanomedicine for personalized disease diagnosis and treatment. Finally, the current challenges and future development prospects of cell membrane bionic nanomedicine are prospected, which provides ideas for the further development and clinical transformation of cell membrane bionic nanomedicine.





Figure 2. The application of nanomedicine with cell membrane biomimetic in tumor treatment




Figure 3. The mechanism of cell membrane biomimetic nanomedicine to treat bacterial infection







Figure 4. The superiority of cell membrane biomimetic nanomedicine in the treatment of brain diseases




Figure 5. The superiority of cell membrane biomimetic nanomedicine in the treatment of RA
The rapid development of bionic nanomedicine has brought more help to human health. By coating the cell membrane on the surface of the nanoparticles to obtain the bionic nanomedicine of the cell membrane, a new door has been opened, bringing unlimited hope. At the same time, there are many problems in this field that need to be solved urgently, requiring the joint efforts of scientists in different fields!
References Hao, H., Chen, Y. & Wu, M. Biomimetic nanomedicine toward personalized disease theranostics. Nano Res. (2020). DOI: 10.1007/s12274-020-3265-zhttps://doi.org/10.1007/ s12274-020-3265-z
About the author Wu Meiying, associate professor at Sun Yat-sen University, deputy director of the Department of Pharmacy, School of Pharmacy (Shenzhen), winner of the Guangdong Provincial Outstanding Youth Fund, Guangdong Special Support Program Science and Technology Innovation Young Top Talent, mainly engaged in drug/gene delivery systems, biological materials and molecular pharmacy Studies in the fields of science. He has published more than 30 SCI papers in academic journals such as Nat. Commun. and Adv. Mater., many of which were selected as ESI highly cited papers or cover papers, applied for more than 10 national invention patents, and authorized 6 items. Presided over the National Natural Science Foundation of China General Program and Youth Fund, Guangdong Outstanding Youth Science Fund, Shenzhen Basic Research General Program, etc., and mainly participated in major national scientific research instrument development projects. Served as a young editorial board member of journals such as Chinese Chemical Letters and Smart Materials in Medicine, as well as a member of the Molecular Imaging Branch of the Guangdong Society of Precision Medicine Applications.
Chen Yu is a professor at Shanghai University, a doctoral supervisor, a winner of the National Natural Science Foundation of China's Outstanding Youth Fund, a special project leader of the National Key R&D Program "Young Scientist", and an outstanding academic leader in Shanghai. The main research work focuses on the controllable preparation, biological effects of biomedical materials and their applications in biomedicine, including molecular imaging, targeted drug delivery, cranial nerve diseases, tissue engineering, tumor diagnosis and treatment, etc. As the first or corresponding author, he has published more than 150 SCI papers in academic journals such as Nat. Commun. The papers have been cited more than 17,000 times, with an H-index of 70, and have been continuously selected as "Global Highly Cited Scientists in 2018, 2019 and 2020" ". Authorized 7 national invention patents. More than 30 papers were selected as ESI Highly Cited Papers.