1. Journal Source: Frontiers in Immunology


2. Title: Gut microbiota as a biomarker and modulator of anti-tumor immunotherapy outcomes


3. Research Highlights: This article systematically summarizes the regulatory patterns of gut microbial taxa amenable to targeted intervention in melanoma, lung cancer, colorectal cancer, liver cancer, ovarian cancer and urological tumors. It elucidates how gut microbiota participate in the response regulation of immune checkpoint inhibitors by coordinating with immune cells such as dendritic cells and CD8⁺ T cells via metabolites and pattern molecules.


4. Innovations: Functional targeted genera are summarized by tumor type, and signaling pathways mediated by distinct microbiota are differentiated; the disruptive effects of antibiotic-induced perturbation of microbiota homeostasis on targeted immunotherapy are outlined; the divergent molecular pathways through which different bacterial strains activate anti-tumor immunity are compared.


5. Material Development (1) Materials: Multiple gut commensal strains for targeted regulation, including Bifidobacterium, Akkermansia muciniphila, Clostridium butyricum, Lactobacillus reuteri, etc. (2) Functions: Secrete active components such as peptidoglycan, Amuc proteins and short-chain fatty acids, target and activate TLR-related signaling, modulate the release of cytokines including interferons and interleukins, and reshape the immune status of the tumor microenvironment.


6. Extended Research Directions: Further explore metabolites of microbiota with targeting potential; investigate the synergistic immunomodulatory effects of combined bacterial strains; expand the efficacy differences of various targeted microbiota combinations across more tumor types.

#GutMicrobiota #TargetedRegulation #TumorImmunotherapy #ImmuneCheckpointInhibitor #Microbiome #LiteratureSharing

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