(1) Journal source: Advanced Science, May 7, 2026

(2) Title: Aptamer‑Directed Porous DNA Nanocomposite Hydrogel for Active Pulp Preservation: Immunomodulation, Stem Cell Recruitment and Reparative Dentinogenesis

(English title retained as provided)

(3) Research rationale: This work designs an aptamer‑directed porous DNA nanocomposite hydrogel and investigates it using a pulp injury model. Leveraging the hydrogel’s porous network and aptamer targeting capability, the study explores its mechanisms in regulating the local immune microenvironment, recruiting endogenous stem cells, and triggering reparative dentin formation.

(4) Innovations: Introduction of aptamer targeting into porous DNA hydrogel systems; in situ photocrosslinkable fabrication with concurrent immunomodulation and endogenous stem cell recruitment; induction of reparative dentin formation using DNA‑based materials, offering a new design strategy for pulp preservation biomaterials.

(5) Material development

1. Material: Aptamer‑directed porous DNA nanocomposite hydrogel

2. Functions: In situ photocuring, modulation of the local immune microenvironment, recruitment of endogenous stem cells, induction of reparative dentin formation, for pulp injury repair applications.

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