Journal Source Advanced Functional Materials

Title Polymeric Nanoparticles Co‑Deliver Cationic‑Polymer Sonosensitizer and Antimicrobial‑Peptide Mimetic for Enhanced Therapy of Lethal Bacterial Pneumonia

Research Idea This study designs inhalable polymeric nanoparticles. Ultrasound‑triggered sonodynamic effects mediate drug release, while cationic moieties enable bacterial targeting. Integrating direct bactericidal action and host immunomodulatory effects, the nanoparticles achieve multimodal synergistic therapy for bacterial pneumonia.

Innovations A multimodal synergistic antibacterial system integrating sonodynamic effect, cation‑mediated targeting and immune regulation is constructed, offering a non‑antibiotic therapeutic strategy for pulmonary infections caused by multidrug‑resistant bacteria.

Material Development ① Materials: ROS‑responsive amphiphilic polymeric nanoparticle SK5.3 encapsulating cationic‑polymer sonosensitizer and cationic antimicrobial‑peptide mimetic. ② Functions: Under ultrasound stimulation, reactive oxygen species are generated and nanoparticles dissociate, realizing bacterial targeting and direct bactericidal effects. Meanwhile, they modulate host inflammatory responses and facilitate tissue repair.

Medicine‑Engineering Intersection｜Project Design｜Custom‑Tailored Materials

1. Experimental protocol design for nanomaterials and nanomedicine (material synthesis, characterization, cell and animal studies; detailed experimental reports supplied with authentic, traceable exclusive datasets)
2. Project concept design: medical‑oriented solution construction. Innovative project schemes tailored to research disciplines and hot‑spot topics to support top‑journal publications.
3. Synthesis of bionanomaterials: biological hydrogels, MXenes, MAX phases, MOFs, COFs, nanozymes, quantum dots and others.

We provide full-process services for custom material design, including innovative scheme design, fabrication, characterization, and in vitro & in vivo validation (cell and animal studies). Our postdoctoral team with multiple high-impact Q1 publications can tackle your challenging research demands. Our scope covers hydrogels, drug delivery systems, nanomaterials, polymers, liposomes, microneedles and more. We support project design, NSFC proposal writing, and high-quality SCI manuscripts for journals such as AFM, AM and other Q1/Q2 journals. Enquiries are welcome👇

17768014569 (Dr.Gao)

17761925168 (Dr. Zhang)

18013729810 (Dr. Yang)

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