1. Journal source:Journal of Nanobiotechnology

2. Title:

Emerging potential of engineered nanozymes in periodontitis treatment: from monotherapy to hierarchical therapy

3. Research rationale:

This review systematically discusses the design strategies and application prospects of engineered nanozymes for periodontitis treatment. It proposes a framework of “hierarchical therapy”, emphasizing the construction of stage-responsive nanoplatforms according to disease progression and pathological stages to achieve sequential synergy of antibacterial action, anti‑inflammation and tissue regeneration.

4. Material development:

Materials: Engineered nanozymes designed via strategies including element doping, heterostructure construction and surface modification (e.g., Fe‑B/N‑C, CuCeOₓ, MnO₂@hPM).

Functions: Integrated multifunctions including antibacterial activity, ROS regulation, immune microenvironment remodeling and promotion of bone regeneration.

5. Innovation:

The concept of “hierarchical therapy” for periodontitis is proposed for the first time. Pathological signal‑triggered sequential activation and synergy of therapeutic functions are realized, advancing nanozymes from single‑function agents toward intelligent cascade theranostic systems.

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