EcN@Gel
| 【Numbering】BKMC121007 | 【CAS】CAS | ||
| 【Item No.】BKMC121007-2 | 【specification】 | ||
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Name: EcN @ Gel
Composition: EcN NH2-GG GF F-OHNQ-GGGFF
Particle size: 1-5 μ m
Application: inflammatory bowel disease
Storage conditions: -4℃
Other instructions: shelf life of half a year in sealed state [Main Advantages] A new nitroreductase (NTR) unstable peptide hydrogel based on supramolecular self-assembly. The efficient encapsulation of 1917 (EcN) of the typical probiotic Escherichia coli Nissle, into the supramolecular assembly produced a hydrogel loaded with probiotics (EcN @ Gel). This hydrogel adequately protects EcN to enhance its viability to resist harsh acid and bile salt environments during oral administration. Upregulated NTR in the gut triggers the breakdown of the hydrogel and achieves locally controlled release of EcN.
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Composition: EcN NH2-GG GF F-OHNQ-GGGFF
Particle size: 1-5 μ m
Application: inflammatory bowel disease
Storage conditions: -4℃
Other instructions: shelf life of half a year in sealed state [Main Advantages] A new nitroreductase (NTR) unstable peptide hydrogel based on supramolecular self-assembly. The efficient encapsulation of 1917 (EcN) of the typical probiotic Escherichia coli Nissle, into the supramolecular assembly produced a hydrogel loaded with probiotics (EcN @ Gel). This hydrogel adequately protects EcN to enhance its viability to resist harsh acid and bile salt environments during oral administration. Upregulated NTR in the gut triggers the breakdown of the hydrogel and achieves locally controlled release of EcN.
Title:Reductase-Labile Peptidic Supramolecular Hydrogels Aided in Oral Delivery of Probiotics
Article link:https://pubs.acs.org/doi/10.1021/acsami.3c04408
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