Dc&Ce6@MBNP
| 【Numbering】BKMC117005 | 【CAS】CAS | ||
| 【Item No.】BKMC117005-2 | 【specification】 | ||
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Name: Dc & Ce 6 @ MBNP
Composition: Dc, Ce 6, and BR-PEG2000-M
Particle size: 100 nm
Application: Inhibition of glycolysis, angiogenesis, and hypoxia pathways
Storage conditions: -4℃
Other instructions: shelf life of half a year under sealed state [Main advantages] Morphine has the charge flipping ability of pH response, which can change from negative electricity to positive electricity in the acidic tumor microenvironment, and improve the endocytosis of nanoparticles by tumor cells. On the other hand, with the 650 nm near-infrared laser, the photosensitizer produces a large amount of ROS, kills the tumor, and can destroy the ROS-responsive bilirubin nanoparticles and release diclofenac. The released diclofenac can inhibit the protein expression and enzyme viability of LDHA, inhibit lactate production, reduce various growth factors associated with angiogenesis, and inhibit neoangiogenesis. Alternatively, diclofenac was found to inhibit HIF-1 α and c-MYC expression, further reversing the hypoxic side effects.
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Composition: Dc, Ce 6, and BR-PEG2000-M
Particle size: 100 nm
Application: Inhibition of glycolysis, angiogenesis, and hypoxia pathways
Storage conditions: -4℃
Other instructions: shelf life of half a year under sealed state [Main advantages] Morphine has the charge flipping ability of pH response, which can change from negative electricity to positive electricity in the acidic tumor microenvironment, and improve the endocytosis of nanoparticles by tumor cells. On the other hand, with the 650 nm near-infrared laser, the photosensitizer produces a large amount of ROS, kills the tumor, and can destroy the ROS-responsive bilirubin nanoparticles and release diclofenac. The released diclofenac can inhibit the protein expression and enzyme viability of LDHA, inhibit lactate production, reduce various growth factors associated with angiogenesis, and inhibit neoangiogenesis. Alternatively, diclofenac was found to inhibit HIF-1 α and c-MYC expression, further reversing the hypoxic side effects.
Title:Co-delivery of photosensitizer and diclofenac through sequentially responsive bilirubin nanocarriers for combating hypoxic tumors
Article link:https://mp.weixin.qq.com/s?src=11×tamp=1689143141&ver=4645&signature=bhvXdzODmSIvOnWUqfQlrbOz1Y04cG2WoWOOklYplQagTQFxaaDCyhUgsZp-BdAJFRzAg*yFC96nibKoXZyyjklB1eJZMq0ZT*iUvt-wwkUq*lDg53fqEKMIeHXy8shg&new=1
| Warm tips: Suzhou Beike nano products are only used for scientific research, not for human body,different batches of products have different specifications and performance |
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| Warm tips: Suzhou Beike nano products are only used for scientific research, not for human body,different batches of products have different specifications and performance.The website pictures are from the Internet. The pictures are for reference only. Please take the real object as the standard. In case of infringement, please contact us to delete them immediately. |
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