GNRa-CSP12
| 【Numbering】BKMC116002 | 【CAS】CAS | ||
| 【Item No.】BKMC116002-2 | 【specification】 | ||
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Name: GNRa-CSP 12
Composition: Chitosan + 12-peptide + gold nanorods
Particle size: about 13,021 nm
Application: Treatment of acute myeloid leukemia
Storage conditions: -4℃
Other instructions: shelf life of half a year under sealed state [Main advantages] Low dose GNRa-CSP 12 can inhibit the growth of leukemic cells by damaging redox balance and inducing iron death. Mechanistic studies suggest that GNRa-CSP 12 is able to enable inactivity against endogenous Fe2 + -dependent m6A demethylase, resulting in m6A hypomethylation and post-transcriptional regulation of downstream genes. Combined treatment with GNRa-CSP 12 and tyrosine kinase inhibitors (TKIs) synergistically abolished the m6A-mediated TKI resistance phenotype.
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Composition: Chitosan + 12-peptide + gold nanorods
Particle size: about 13,021 nm
Application: Treatment of acute myeloid leukemia
Storage conditions: -4℃
Other instructions: shelf life of half a year under sealed state [Main advantages] Low dose GNRa-CSP 12 can inhibit the growth of leukemic cells by damaging redox balance and inducing iron death. Mechanistic studies suggest that GNRa-CSP 12 is able to enable inactivity against endogenous Fe2 + -dependent m6A demethylase, resulting in m6A hypomethylation and post-transcriptional regulation of downstream genes. Combined treatment with GNRa-CSP 12 and tyrosine kinase inhibitors (TKIs) synergistically abolished the m6A-mediated TKI resistance phenotype.
Title:Gold Nanorods Exhibit Intrinsic Therapeutic Activity via Controlling N6‑MethyladenosineBased Epitranscriptomics in Acute Myeloid Leukemia
Article link:https://www.163.com/dy/article/GOQ99DD70552LBIY.html
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