PPy-FePO-Gox-PVA
| 【Numbering】BKMC106013 | 【CAS】CAS | ||
| 【Item No.】BKMC106013-2 | 【specification】 | ||
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Name: PPy-FePO-Gox-PVA
Composition: Polyvinyl alcohol + FePO cluster + pyrrole monomer + GOx
Grain size: 50-200nm
Application: anti-tumor
Storage conditions: -4℃
Other instructions: shelf life of half a year in sealed state [Main advantages] When tumors are administered, GOx will deplete glucose, cut off the energy supply, and destroy the heat resistance mechanism of tumor cells. Glucaric acid and hydrogen peroxide, as metabolites, promoted the occurrence of Fenton reaction from hydroxyl generation. Meanwhile, the Fe (III) -induced GSH depletion process disrupts the antioxidant capacity of tumor cells. LPO thus accumulates through the ferroptosis pathway, leading to cell death. Under NIR light irradiation, produce hyperthermia, induced apoptosis, and promoting the catalytic efficiency of the Fenton reaction, with a synergistic effect.
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Composition: Polyvinyl alcohol + FePO cluster + pyrrole monomer + GOx
Grain size: 50-200nm
Application: anti-tumor
Storage conditions: -4℃
Other instructions: shelf life of half a year in sealed state [Main advantages] When tumors are administered, GOx will deplete glucose, cut off the energy supply, and destroy the heat resistance mechanism of tumor cells. Glucaric acid and hydrogen peroxide, as metabolites, promoted the occurrence of Fenton reaction from hydroxyl generation. Meanwhile, the Fe (III) -induced GSH depletion process disrupts the antioxidant capacity of tumor cells. LPO thus accumulates through the ferroptosis pathway, leading to cell death. Under NIR light irradiation, produce hyperthermia, induced apoptosis, and promoting the catalytic efficiency of the Fenton reaction, with a synergistic effect.
Title:Polypyrrole-iron phosphate-glucose oxidase-based nanocomposite with cascade catalytic capacity for tumor synergistic apoptosis-ferroptosis therapy
Article link:https://doi.org/10.1016/j.cej.2021.131671
| Warm tips: Suzhou Beike nano products are only used for scientific research, not for human body,different batches of products have different specifications and performance |
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