ipGdIO-Dox
| 【Numbering】BKMC106009 | 【CAS】CAS | ||
| 【Item No.】BKMC106009-2 | 【specification】 | ||
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Name: ipGdIO-Dox
Composition: MRICAs (GdIO) + doxorubicin + iRGD-PEG-ss-PEG
Grain size: 50-200nm
Application: Ionic visual sensing
Storage conditions: -4℃
Other instructions: shelf life of half a year in sealed state [Main advantage] The iRGD-PEG-ss-PEG chain on the surface of ipGdIO-Dox is cleaved by exhausting GSH and then releasing Dox. GSH inactivates GPX 4 expression and further promotes the accumulation of ROS, thus enhancing iron death. At the same time, exposed GdIO responds quickly to ATME and then releases a large number of iron ions, promoting the generation of cellular ROS and accelerating iron death. In addition, the released doxorubicin can quickly enter the nucleus, inhibit DNA replication, and then induce the apoptosis of tumor cells, to achieve the ideal tumor chemotherapy.
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Composition: MRICAs (GdIO) + doxorubicin + iRGD-PEG-ss-PEG
Grain size: 50-200nm
Application: Ionic visual sensing
Storage conditions: -4℃
Other instructions: shelf life of half a year in sealed state [Main advantage] The iRGD-PEG-ss-PEG chain on the surface of ipGdIO-Dox is cleaved by exhausting GSH and then releasing Dox. GSH inactivates GPX 4 expression and further promotes the accumulation of ROS, thus enhancing iron death. At the same time, exposed GdIO responds quickly to ATME and then releases a large number of iron ions, promoting the generation of cellular ROS and accelerating iron death. In addition, the released doxorubicin can quickly enter the nucleus, inhibit DNA replication, and then induce the apoptosis of tumor cells, to achieve the ideal tumor chemotherapy.
Title:Efficient Magnetic Nanocatalyst-Induced Chemo- and Ferroptosis Synergistic Cancer Therapy in Combination with T1−T2 Dual-Mode Magnetic Resonance Imaging Through Doxorubicin Delivery
Article link:https://pubs.acs.org/doi/10.1021/acsami.1c17507
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