SAS/DOX@OHS-PEG
| 【Numbering】BKMC106006 | 【CAS】CAS | ||
| 【Item No.】BKMC106006-2 | 【specification】 | ||
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Name: SAS / DOX @ OHS-PEG
Composition: Sulfonazine (SAS) + Dxorubicin (DOX) + C sphere PEG Ag
Size: 200-500nm
Application: Ion visual sensing
Storage conditions: -4℃
Other instructions: shelf life of half a year in sealed state [Main advantages] SAS / DOX @ OHS-PEG can reach the tumor site through the well-known enhanced permeability and retention (EPR) effect and release SAS and DOX stimulated by high concentration of glutathione (GSH) at the tumor site. As a sulfonamide antimicrobial aging drug, SAS can inhibit the expression of cystine / glutamate transporter (xCT), leading to the reduction of glutathione peroxidase 4 (GPX 4) synthesis content, leading to iron apoptosis of tumor cells. Meanwhile, the classical chemotherapeutic drug DOX induced pyroptosis through caspase-3-dependent lysis of gasderin E (GSDME).
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Composition: Sulfonazine (SAS) + Dxorubicin (DOX) + C sphere PEG Ag
Size: 200-500nm
Application: Ion visual sensing
Storage conditions: -4℃
Other instructions: shelf life of half a year in sealed state [Main advantages] SAS / DOX @ OHS-PEG can reach the tumor site through the well-known enhanced permeability and retention (EPR) effect and release SAS and DOX stimulated by high concentration of glutathione (GSH) at the tumor site. As a sulfonamide antimicrobial aging drug, SAS can inhibit the expression of cystine / glutamate transporter (xCT), leading to the reduction of glutathione peroxidase 4 (GPX 4) synthesis content, leading to iron apoptosis of tumor cells. Meanwhile, the classical chemotherapeutic drug DOX induced pyroptosis through caspase-3-dependent lysis of gasderin E (GSDME).
Title:Ferroptosis and Pyroptosis Co-Activated Nanomodulator for “Cold” Tumor Immunotherapy and Lung Metastasis Inhibition
Article link:https://doi.org/10.1002/adfm.202211698
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